SEQUENCE Pilot 5.4.6: ACMG Classification Tool

Highlights: New ACMG/AMP criteria workflow with documented rationale, Transparent evidence overview & final classification, Reproducible classification for routine reporting

Highlights for SEQUENCE Pilot version 5.4.6: ACMG Classification Tool:

  • Structured criteria workflow: assign ACMG/AMP criteria step by step and document the rationale for each decision

  • Transparent overview: keep track of applied evidence in a clear matrix and see the resulting classification at a glance

  • Consistency in routine work: improve reproducibility across users and enable harmonized reporting within the laboratory

  • Optional database context: public variant database information can be shown directly in the tool when using the SQLite public SNP databases

For a complete list of changes and update instructions, please contact the JSI support team.

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